Pomegranate (Punica granatum L.) peel hydro alcoholic extract ameliorates cardiovascular risk factors in obese women with dyslipidemia: A double blind, randomized, placebo controlled pilot study

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• 作者：Mahdiyeh Khadem Haghighian^a ; ^{mah_kh1362@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Maryam Rafraf^a ; ^{rafrafm@tbzmed.ac.ir" class="auth_mail" title="E-mail the corresponding author} ; Abdolvahab Moghaddam^b ; ^{vahab_m583@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Salar Hemmati^c ; ^{salarhemati@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mohammad Asghari Jafarabadi^d ; ^{M.asghari862@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Bahram Pourghassem Gargari^e ; ^{pourghasemb@tbzmed.ac.ir" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Punicaceae ; Cardiovascular ; Obese ; Dyslipidemia ; pomegranate ; randomized controlled trial
• 刊名：European Journal of Integrative Medicine
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：8
• 期：5
• 页码：676-682
• 全文大小：538 K

文摘

Dyslipidemia is one of the most important risk factors for cardiovascular disease. Previous studies have shown that pomegranate and its polyphenols may have hypolipidemic effects. The objective of this study was to evaluate the effects of pomegranate peel extract on some cardiovascular risk factors in patients with dyslipidemia.

Methods

Thirty eight obese women (30< body mass index (BMI) >35 kg/m2) with dyslipidemia were allocated into two groups receiving two 500 mg pomegranate peel extract (n = 19) or placebo (n = 19) daily for 8 weeks. Serum lipid profile (total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), triglycerides (TG)), Blood Pressure(BP), serum high sensitive-C reactive protein (hs-CRP) and BMIwere measured.

Results

Pomegranate peel extract significantly decreased post treatment levels of serum TC (p = 0.014), LDL-C (p = 0.021), and TG (p = 0.036) and increased HDL-C (p = 0.020)compared to baseline. There was a significant decrease in Systolic Blood Pressure (SBP) levels and hs-CRP in pomegranate peel group whereas Diastolic Blood Pressure (DBP) levels and BMI remained unchanged after intervention. No significant changes were seen in terms of all post treatment values for the placebo group at the end of trial (p > 0.05). After adjusting for the baseline values, energy intake and weight changes, there were significant differences in post-treatment values between the two groups except in serum concentrations of HDL-C, DBP and BMI.

Conclusions

Current study showed a positive effect of pomegranate peel extract in improving cardiovascular risk factors in obese women with dyslipidemia.