Natural collagenic skeleton of marine sponges in pharmaceutics: Innovative biomaterial for topical drug delivery
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- 作者：Rita Langascoa ; 1 ; rlangasco@uniss.it" class="auth_mail" title="E-mail the corresponding author ; Barbara Cadeddub ; 1 ; bcadeddu@uniss.it" class="auth_mail" title="E-mail the corresponding author ; Marilena Formatoc ; formato@uniss.it" class="auth_mail" title="E-mail the corresponding author ; Antonio Junior Lepeddac ; ajlepedda@uniss.it" class="auth_mail" title="E-mail the corresponding author ; Massimo Cossua ; m.cossu@uniss.it" class="auth_mail" title="E-mail the corresponding author ; Paolo Giunchedia ; pgiunc@uniss.it" class="auth_mail" title="E-mail the corresponding author ; Roberto Pronzatod ; pronzato@dipteris.unige.it" class="auth_mail" title="E-mail the corresponding author ; Giovanna Rassua ; grassu@uniss.it" class="auth_mail" title="E-mail the corresponding author ; Renata Manconib ; r.manconi@uniss.it" class="auth_mail" title="E-mail the corresponding author ; Elisabetta Gavinia ; eligav@uniss.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Porifera skeleton ; Bioactive-biomimetic material ; Glycosaminoglycan ; Alginate-based film ; Environmentally sustainable formulation ; Novel wound dressing
- 刊名：Materials Science & Engineering C
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：70
- 期：part_P1
- 页码：710-720
- 全文大小：2002 K
文摘
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Marine sponge skeleton is proposed as biomimetic material for pharmaceutical use.
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The biomaterial can be loaded with class="smallcaps">l-cysteine as wound healing drug.
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Selected drug loaded sponge powder shows interesting morpho-functional performances.
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Natural material, due to its composition, can be considered as bio-functional carrier.
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Loaded powder was included in biocompatible film as suitable topical delivery system.