Approaches to drug delivery: Confinement of aspirin in MIL-100(Fe) and aspirin in the de novo synthesis of metal-organic frameworks
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- 作者：Brenda Singco1 ; Li-Hao Liu1 ; Ya-Ting Chen ; Yung-Han Shih ; Hsi-Ya Huang ; hyhuang@cycu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Chia-Her Lin ; chiaher@cycu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Drug delivery ; MIL-100(Fe) ; Aspirin ; Metal&ndash ; organic framework ; Bio-MOFs
- 刊名：Microporous and Mesoporous Materials
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：223
- 期：Complete
- 页码：254-260
- 全文大小：725 K
文摘
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This is first report that aspirin was used as the model drug to encapsulate in MOF.
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Two techniques have been demonstrated in delivering drug using a metal-organic framework (MOF) MIL-100(Fe).
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First method is the encapsulation of a small molecule drug (aspirin) by the MIL-100(Fe) referred as the ASA@MIL-100(Fe).
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The other method is that using de novo synthesis of AH-series MOFs (bio-MOFs) with aspirin was utilized.
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Both drug carriers exhibited potential for a sustained delivery in simulated biological fluids for a prolonged period.