Intermolecular recognition of the non-coding RNA 7SK and HEXIM protein in perspective
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- 作者：Denise Martinez-Zapiena ; b ; c ; d ; e ; d.martinez@unistra.fr" class="auth_mail" title="E-mail the corresponding author ; Jean-Michel Saliouf ; g ; h ; Jean-Michel.Saliou@pasteur-lille.fr" class="auth_mail" title="E-mail the corresponding author ; Xiao Hani ; j ; k ; l ; roxane0313@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Cedric Atmanenef ; g ; cedric.armanene@unistra.fr" class="auth_mail" title="E-mail the corresponding author ; Florence Prouxi ; j ; k ; proux@biologie.ens.fr" class="auth_mail" title="E-mail the corresponding author ; Sarah Cianfé ; ranif ; g ; sarah.cianferani@unistra.fr" class="auth_mail" title="E-mail the corresponding author ; Anne-Catherine Dock-Bregeoni ; j ; k ; dock@biologie.ens.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：non-coding RNA 7SK ; HEXIM ; Molecular interaction ; Native mass spectrometry ; Transcription regulation
- 刊名：Biochimie
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：117
- 期：Complete
- 页码：63-71
- 全文大小：1670 K
文摘
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7SK ncRNA recognition by the HEXIM protein depends on a low-complexity peptide, ARM.
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HEXIM is a dimer, but only one ARM binds the RNA discriminant sequence.
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Binding of the second monomer of HEXIM depends on a sequence downstream of ARM.
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The LARP7 core protein of 7SKsnRNP may participate to HEXIM binding specificity.