Circulating angiogenic cell function is inhibited by cortisol in vitro and associated with psychological stress and cortisol in vivo
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- 作者：Kirstin Aschbachera ; b ; kirstin.aschbacher@ucsf.edu" class="auth_mail" title="E-mail the corresponding author ; Ronak Derakhshandehc ; Abdiel J. Floresd ; Shilpa Narayanc ; Wendy Berry Mendesa ; 1 ; Matthew L. Springerc ; e ; f ; 1
- 关键词：Angiogenesis ; Endothelial progenitor cells ; Circulating hematopoietic progenitor cells ; Executive function ; Sustained attention ; Anxiety
- 刊名：Psychoneuroendocrinology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：67
- 期：Complete
- 页码：216-223
- 全文大小：646 K
文摘
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We model social threat in interracial interactions among African Americans.
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We assayed circulating angiogenic cell (CAC) function, a marker of vascular repair.
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In vivo, threat was associated with higher cortisol and decreased CAC function.
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In vitro, cortisol inhibited CAC function.
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Social threat may impact vascular repair via a cortisol-CAC pathway.
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