Selective alterations of NMDAR function and plasticity in D1 and D2 medium spiny neurons in the nucleus accumbens shell following chronic intermittent ethanol exposure
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- 作者：Rafael Renteriaa ; rrenteria630@utexas.edu" class="auth_mail" title="E-mail the corresponding author ; Esther Y. Maierb ; emaier@utexas.edu" class="auth_mail" title="E-mail the corresponding author ; Tavanna R. Buskeb ; tporter@utexas.edu" class="auth_mail" title="E-mail the corresponding author ; Richard A. Morrisetta ; b ; c ; ramorris@austin.utexas.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neuroadaptation ; CIE ; LTD ; LTP
- 刊名：Neuropharmacology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：112
- 期：part_PA
- 页码：164-171
- 全文大小：989 K
文摘
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NMDAR-dependent LTD is expressed only in D1 MSNs of EtOH naïve mice.
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After CIE, the LTD induction protocol results in LTP in D1 MSNs and LTD in D2 MSNs.
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CIE induces an increase in excitability and sEPSC frequency in D1 MSNs.
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NMDAR function is increased and decreased in D1 and D2 MSNs respectively after CIE.
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Altered NMDAR function may be important for the development of EtOH dependence.