The MC1R Gene and Youthful Looks
详细信息 查看全文
- 作者：Fan Liu1 ; 2 ; Merel A. Hamer3 ; Joris Deelen4 ; Japal S. Lall5 ; Leonie Jacobs3 ; Diana van Heemst6 ; Peter G. Murray5 ; Andreas Wollstein2 ; 7 ; Anton J.M. de Craen6 ; Hae-Won Uh8 ; Changqing Zeng1 ; Albert Hofman9 ; André ; G. Uitterlinden9 ; 10 ; Jeanine J. Houwing-Duistermaat8 ; 11 ; Luba M. Pardo3 ; Marian Beekman4 ; P. Eline Slagboom4 ; Tamar Nijsten3 ; Manfred Kayser2 ; 12 ; m.kayser@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author ; David A. Gunn5 ; 12 ; david.gunn@unilever.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：perceived facial age ; MC1R ; GWAS ; skin ; facial aging ; appearance ; age
- 刊名：Current Biology
- 出版年：2016
- 出版时间：9 May 2016
- 年：2016
- 卷：26
- 期：9
- 页码：1213-1220
- 全文大小：1288 K
文摘
- •
We present the first genetic associations with how old people look (perceived age)
- •
Variants in MC1R, a pigmentation gene, significantly associated with perceived age
- •
The MC1R association was independent of wrinkling, skin color, and sun exposure
- •
The MC1R genetic effect resulted in looking up to 2 years older for one’s age