Low-dose norfloxacin and ciprofloxacin therapy worsen leptospirosis in hamster

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• 作者：Dianjun Wu^a ; ^b ; ¹ ; Wenlong Zhang^b ; ¹ ; Tingting Wang^b ; Tao Lin^c ; Xuemin Jin^b ; Xufeng Xie^b ; Jian Guo^b ; Yongguo Cao^b ; ^{ygcao82@jlu.edu.cn} ; Rui Wu^a ; ^{fuhewu@126.com}
• 刊名：Microbial Pathogenesis
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：102
• 期：Complete
• 页码：36-41
• 全文大小：2011 K
• 卷排序：102

文摘

The risk associated with low-dose norfloxacin and ciprofloxacin in leptospirosis. Low-dose norfloxacin and ciprofloxacin reduced survival rate. Low-dose norfloxacin increased bacterial loads in target organs. Low-dose norfloxacin aggravated tissue injury of target organs. Low-dose norfloxacin delayed induction of IL-1β and TNF-α in tissues.