Fibrinolytic PLGA nanoparticles for slow clot lysis within abdominal aortic aneurysms attenuate proteolytic loss of vascular elastic matrix
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- 作者：Balakrishnan Sivaramana ; Andrew Sylvestera ; b ; Anand Ramamurthia ; b ; ramamua@ccf.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nanoparticles ; Fibrinolysis ; Elastic matrix ; Regenerative matrix repair ; Aortic aneurysms ; Smooth muscle cells
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：59
- 期：Complete
- 页码：145-156
- 全文大小：1098 K
文摘
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Formulated tPA-releasing PLGA NPs for slow lysis of fibrin-rich clots within small AAAs
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NP-delivered tPA achieves much slower clot lysis versus equivalent dose of exogenous tPA.
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NP-released tPA attenuates proteolysis and limits elastic matrix loss versus exogenous tPA.
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NPs with cationic surfaces show improved clot binding and slowed clot lysis versus anionic NPs.