Modeling tumor growth in the presence of a therapy with an effect on rate growth and variability by means of a modified Gompertz diffusion process
详细信息 查看全文
- 作者：Patricia Romá ; n-Romá ; na ; ; Sergio Romá ; n-Romá ; nb ; Juan José ; Serrano-Pé ; reza ; Francisco Torres-Ruiza
- 关键词：Gompertz diffusion process ; Antiproliferative therapy ; Tumor growth ; PDX tumor model
- 刊名：Journal of Theoretical Biology
- 出版年：2016
- 出版时间：21 October 2016
- 年：2016
- 卷：407
- 期：Complete
- 页码：1-17
- 全文大小：1465 K
文摘
- •
A modification of a Gompertz diffusion process is considered.
- •
The new process includes time functions in its infinitesimal mean and variance.
- •
Combinations of procedures in order to estimate the model have been proposed.
- •
An application about the effects of cisplatin on a PDX tumor model has been performed.
- •
The model reproduces more accurately the tumor growth that previous models.