Synthesis, sustained release properties of magnetically functionalized organic–inorganic materials: Amoxicillin anions intercalated magnetic layered double hydroxides via calcined precursors at

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• 作者：Jun Wang ; Qi Liu ; Guangchun Zhang ; Zhanshuang Li ; Piaoping Yang ; Xiaoyan Jing ; Milin Zhang ; Tianfu Liu ; Zhaohua Jiang
• 关键词：Layered double hydroxides ; Amoxicillin ; Sustained release ; Drug-targeting delivery ; Magnetite
• 刊名：Solid State Sciences
• 出版年：2009
• 出版时间：September 2009
• 年：2009
• 卷：11
• 期：9
• 页码：1597-1601
• 全文大小：394 K

文摘

Zinc–aluminum–carbonate–layered double hydroxides (ZnAl–CO₃–LDHs), loaded with magnetic substrates (Fe₃O₄), were prepared for sustained drug-targeting delivery. From the X-ray diffraction results, it was found that the magnetic substrates were successfully incorporated with LDHs and highly dispersed in the hydrotalcite structure. After intercalation with an antibiotic drug (amoxicillin) by using a calcinations–reconstruction method, the basal spacing of layered double hydroxides increased from 7.51 Å to 12.35 Å, indicating that amoxicillin was successfully intercalated into the interlay space of LDHs as a monolayer. Furthermore, in vitro drug release experiments in pH 7.4 phosphate buffer solution (PBS) showed sustained release profiles with amoxicillin as a model drug. Magnetic measurements revealed that the composite possessed paramagnetic properties at room temperature.