C14orf93 (RTFC) is identified as a novel susceptibility gene for familial nonmedullary thyroid cancer

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• 作者：Chang Liu^a ; ¹ ; Yang Yu^b ; ¹ ; Guangliang Yin^c ; ¹ ; Junxia Zhang^a ; Wei Wen^a ; Xianhui Ruan^b ; Dapeng Li^b ; Shuang Zhang^d ; Wenjun Cai^c ; Ming Gao^b ; ^{gaoming68@aliyun.com} ; Lingyi Chen^a ; ^e ; ^{lingyichen@nankai.edu.cn}
• 关键词：Thyroid cancer ; Exome sequencing ; C14orf93 ; RTFC
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：590-596
• 全文大小：1541 K
• 卷排序：482

文摘

C14orf93 (RTFC) is identified as a susceptibility gene in a FNMTC family. Two more RTFC mutations, V205M and G209D, are found in sporadic NMTC patients. V205M, G209D, and R115Q RTFC mutants are pro-tumorigenic.