Anti-inflammatory effect of meloxicam on experimental vasospasm in the rat femoral artery

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• 作者：Tayfun Hakan ; M. Zafer Berkman ; Turgay Ersoy ; İ ; smail Karataş ; Tangü ; l Ş ; an ; Serap Arbak
• 关键词：Cerebral vasospasm ; Femoral artery ; Inflammation ; Meloxicam ; Subarachnoid haemorrhage
• 刊名：Journal of Clinical Neuroscience
• 出版年：2008
• 出版时间：January 2008
• 年：2008
• 卷：15
• 期：1
• 页码：55-59
• 全文大小：1481 K

文摘

Cerebral vasospasm influences morbidity and mortality following subarachnoid haemorrhage (SAH). Inflammation is believed to play a role in post-haemorrhagic vasospasm. Meloxicam is a non-steroidal anti-inflammatory drug. We investigated the effect of meloxicam on a rat femoral artery vasospasm model using the radial wall thickness and cross-sectional lumen area as parameters under light, scanning and transmission electron microscopy examination. Rats were randomly separated into SAH, SAH + meloxicam and control groups. Rats in the SAH + meloxicam group were given meloxicam at 2 mg/kg daily for 7 days. Femoral arteries were examined by light microscopy and scanning and transmission electron microscopy, and for morphometric analysis. A statistically significant difference (p < 0.001) was detected between the SAH and SAH + meloxicam groups. Meloxicam treatment reduced ultrastructural and morphometric vasospastic changes. These findings support the hypothesis that inflammation may play a role in the pathophysiologyical pathways of post-haemorrhagic cerebral vasospasm.