Postoperative serum CEA and CA125 levels are supplementary to perioperative CA19-9 levels in predicting operative outcomes of pancreatic ductal adenocarcinoma

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• 作者：Hua-Xiang Xu ; MD ; PhD^&lowast ; ; Liang Liu ; MD ; PhD^&lowast ; ; Jin-Feng Xiang ; MD^&lowast ; ; Wen-Quan Wang ; MD ; PhD^&lowast ; ; Zi-Hao Qi ; MD ; PhD ; Chun-Tao Wu ; MD ; Chen Liu ; MD ; PhD ; Jiang Long ; MD ; PhD ; Jin Xu ; MD ; PhD ; Quan-Xing Ni ; MD ; PhD ; Xian-Jun Yu ; MD ; PhD ; ^{yuxianjun@fudanpci.org} ; ^{yuxianjun@fudan.edu.cn}
• 刊名：Surgery
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：161
• 期：2
• 页码：373-384
• 全文大小：1539 K
• 卷排序：161

文摘

Carbohydrate antigen (CA19-9) is a well-established marker to monitor disease status after resection of pancreatic cancer. However, few serum markers have been reported to improve the prognostic ability of postoperative CA19-9, especially in patients with normal postoperative CA19-9.MethodsA total of 353 patients with pancreatic ductal adenocarcinoma treated by radical resection were reviewed retrospectively, and a prospective cohort including 142 patients with resectable pancreatic head carcinoma was analyzed as a validation cohort. Perioperative CA19-9 and postoperative serum markers (CEA, CA242, CA72-4, CA50, CA125, CA153, and AFP) were investigated.ResultsPatients with postoperative normalization of CA19-9 had improved survival times (recurrence-free survival: 11.9 months; overall survival: 22.5 months) compared with those with decreased but still elevated postoperative CA19-9 (recurrence-free survival: 6.8 months, P < .001; overall survival: 13.5 months, P < .001) or those with increased postoperative CA19-9 (recurrence-free survival: 3.5 months, P < .001; overall survival: 7.9 months, P < .001), which was similar to those with consistently normal CA19-9 during perioperative periods (recurrence-free survival: 10.6 months, P = .799; overall survival: 24.1 months, P = .756). Normal postoperative CA19-9 levels were an independent indicator for a positive outcome after operation, regardless of preoperative CA19-9 levels. Elevated postoperative CEA and CA125 were identified further as independent risk factors for patients with normal postoperative CA19-9, while elevated postoperative CA125 and nondecreased postoperative CA19-9 were independent prognostic markers for patients with elevated postoperative CA19-9.ConclusionThe postoperative monitoring of CEA and CA125 provided prognostic significance to the measurement of CA19-9 in pancreatic cancer after resection.