Histamine in diabetes: Is it time to reconsider?

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• 作者：Alessandro Pini^a ; ^{apini@unifi.it" class="auth_mail" title="E-mail the corresponding author} ; Ilona Obara^b ; ^{ilona.obara@durham.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Emma Battell^c ; ^{emma.battell@durham.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Paul L. Chazot^c ; ^{paul.chazot@durham.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Arianna Carolina Rosa^c ; ^d ; ^{acrosa@unito.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：ADP ; action potential duration ; AGEs ; advanced glycation end-products ; BM ; basement membrane ; BRB ; blood-retinal barrier ; CGRP ; calcitonin gene related peptide ; CKD ; chronic kidney disease ; DAO ; diamine oxidase ; DiO ; diet-induced obesity ; ESRD ; end-stage renal disease ; H1-4Rs ; histamine H1-4Rs ; HbA1 ; glycated hemoglobin ; HDC ; histidine decarboxylase ; STZ ; streptozotocin ; TGF-β ; tissue growth factor-β ; TCAs ; tricyclic antidepressants ; Vmax ; maximum rate of depolarization ; VEGF ; vascular endotheli
• 刊名：Pharmacological Research
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：111
• 期：Complete
• 页码：316-324
• 全文大小：1531 K

文摘

The first studies of histamine and diabetes date back to the 1950s. Since that time the involvement of histamine in diabetes was related to its well known vasoactive properties and permeability leakage effects. In particular, the first evidence for a correlation between histamine and diabetes arose in 1989 when an increase in plasma and leucocyte histamine content was observed. Limited independent evidence followed in the subsequent two decades, focusing on both histamine glyceamic control and macro- and microvascular complications of diabetes. However, recent observations have sparked the question whether it is time to reconsider the functional contribution of histamine in diabetes. We reveal an interesting upsurge in the field which provides scope for new insights into the role of histamine in diabetes.