Coenzyme Q₁₀ supplementation in patients with rheumatoid arthritis: Are there any effects on cardiovascular risk factors?

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• 作者：Hadi Abdollahzad^a ; ¹ ; ^{hadi_nut@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Beitollah Alipour^b ; ¹ ; ^{alipourb@tbzmed.ac.ir" class="auth_mail" title="E-mail the corresponding author} ; Mir Amir Aghdashi^c ; ¹ ; ^{maaghdashi@umsu.ac.ir" class="auth_mail" title="E-mail the corresponding author} ; Mohammad Asghari Jafarabadi^d ; ¹ ; ^{m.asghari862@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Lipid profile ; Body weight ; Blood pressure ; Inflammation ; Coenzyme Q10 (CoQ10) ; Rheumatoid arthritis
• 刊名：European Journal of Integrative Medicine
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：7
• 期：5
• 页码：534-539
• 全文大小：458 K

文摘

Rheumatoid arthritis (RA) patients experience higher mortality from cardiovascular events, possibly as a result of systemic inflammation. The aim of this study was to investigate the effects of oral coenzyme Q₁₀ (CoQ₁₀) supplementation on cardiovascular disease (CVD) risk factors in these patients.

Methods

45 RA patients with moderate and severe disease activity (DAS28 > 3.2), participated in this randomized controlled clinical trial. Participants were randomly assigned to CoQ₁₀ or a placebo group. 22 of subjects took 100 mg/day CoQ₁₀ and the remainder took a placebo for 60 days (in addition to conventional medicine). Body weight, systolic and diastolic blood pressure, serum cholesterol, triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL) and C-reactive protein (CRP) were measured before and after intervention. Dietary intake was assessed twice using a three day food record.

Results

At the end of study baseline body weight and LDL in the CoQ₁₀ group reduced significantly (−0.71 kg and −8.58 mg/dL, respectively; p < 0.05). The placebo group showed a significant decrease in total cholesterol and LDL (−10.40 and −11.33 mg/dL, respectively; p < 0.05) and a significant increase in TG (+20.09 mg/dL; p < 0.05). CRP levels did not significantly decrease in CoQ₁₀ and placebo groups (−5.17 vs. −2.97 mg/L). No significant differences were seen between groups regarding body weight, blood pressure, lipid profile and CRP.

Conclusions

60 days supplementation with 100 mg/day CoQ₁₀ showed some indication of a reduction in body weight and LDL but overall no meaningful improvement was seen in CVD risk factors. Studies with larger number of patients, longer follow up and higher doses of the supplement may provide evidence of effectiveness.