Effects of Coenzyme Q₁₀ Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial

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• 作者：Hadi Abdollahzad^a ; Mir Amir Aghdashi^b ; Mohammad Asghari Jafarabadi^c ; Beitollah Alipour^d ; ^{alipourb@tbzmed.ac.ir" class="auth_mail" title="E-mail the corresponding author} ; ^{abdollahzad@kums.ac.ir" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Coenzyme Q10 (CoQ10) ; Ubiquinol ; Inflammatory cytokines ; Oxidative stress ; Rheumatoid arthritis
• 刊名：Archives of Medical Research
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：46
• 期：7
• 页码：527-533
• 全文大小：437 K

文摘

Overproduction of proinflammatory cytokines is a main trait of rheumatoid arthritis. Coenzyme Q₁₀ (CoQ₁₀), an endogenous antioxidant, has shown anti-inflammatory effects in some diseases. In this study we aimed to assess the effects of CoQ₁₀ supplementation on cytokines generation and oxidative stress in rheumatoid arthritis.

Methods

In this double-blind, randomized controlled clinical trial, 44 patients with rheumatoid arthritis were recruited. Twenty two patients received 100 mg/day capsules of CoQ₁₀ and 22 patients took placebo for 2 months. At the beginning and the end of the intervention, 7 mL of fasting blood was taken from patients to measure malondialdehyde (MDA), total antioxidant capacity (TAC), interleukin (IL)-6 and tumor necrosis factor alpha (TNF-α).

Results

At the end of the study, serum MDA significantly decreased in supplemented group (mean difference = −1.47 nmol/mL; 95% confidence interval (CI), −2.52 to −0.43; p = 0.008). CoQ₁₀ also suppressed overexpression of TNF-α (difference in median was +1.1 in placebo vs. +0.03 in CoQ₁₀ group; p = 0.033). There was no significant difference in TAC and IL-6 levels between groups.

Conclusions

This study showed beneficial effects of CoQ₁₀ supplementation on inflammatory cytokines and oxidative stress in rheumatoid arthritis patients.