High fat diet aggravates the nephrotoxicity of berberrubine by influencing on its pharmacokinetic profile
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- 作者：Na Yanga ; Runbin Suna ; Yuqing Zhaoa ; Jun Hea ; Le Zhena ; Jiahua Guoa ; Jianliang Genga ; Yuan Xiea ; Jiankun Wanga ; Siqi Fenga ; Fei Feia ; Xiaoying Liaoa ; Xuanxuan Zhub ; Hongbo Wangc ; Fenghua Fuc ; Jiye Aaa ; jiyea@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Guangji Wanga
- 关键词：BRB ; berberrubine ; BBR ; berberine ; BRBG ; berberrubine-9-O-β-d-glucuronide ; THB ; tetrahydroberberine ; HFD ; high fat diet ; CD ; control diet ; TC ; total cholesterol ; TG ; total triglyceride ; BUN ; clood urea nitrogen ; Cr ; creatinine ; UA ; uric acid ; ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; AKP ; alkaline phosphatase ; AUC ; area under the curve
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：46
- 期：Complete
- 页码：319-327
- 全文大小：3327 K
文摘
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Berberrubine exerted a stronger lipid-lowering effect than berberine in vivo.
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Berberrubine showed a specific nephrotoxicity especially in mice fed with HFD.
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HFD aggravated the nephrotoxicity by influencing on the pharmacokinetic profile.
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In vitro assessment showed berberrubine could produce a toxic effect on renal cells.
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The primary metabolite of berberrubine did not show any obvious toxicity.