Efficacy of topical ALA-PDT combined with excision in the treatment of skin malignant tumor

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• 作者：Yuan-gang Lu ; MD ; Ph.D. ; ^{skin515@163.com" class="auth_mail} ; Yuan-yuan Wang¹ ; ^{quanquan1006@163.com" class="auth_mail} ; Ya-dong Yang¹ ; ^{yangyadong1974@sina.com" class="auth_mail} ; Xing-cun Zhang¹ ; ^{79371465@qq.com" class="auth_mail} ; Yang Gao² ; ^{docgaoyang@126.com" class="auth_mail} ; Yang Yang² ; ^{yangdoublejake@163.com" class="auth_mail} ; Jun-bo Zhang² ; ^{zhangjunbo0924@163.com" class="auth_mail} ; Guo-ling Li² ; ^{258003@qq.com" class="auth_mail}
• 关键词：Topical photodynamic therapy ; Aminolevulinic acid ; Skin malignant tumor ; Surgery
• 刊名：Photodiagnosis and Photodynamic Therapy
• 出版年：June 2014
• 年：2014
• 卷：11
• 期：2
• 页码：122-126
• 全文大小：1035 K

文摘

Photodynamic therapy (PDT) is a successful treatment for non-melanoma skin cancers in clinical practice. In China, more and more doctors use PDT to cure the patients with skin cancer, especially in the elder. The purpose of this study was to evaluate the efficacy of topical PDT using aminolevulinic acid (5-ALA) combined with excision in the treatment of skin malignant tumor and its role in surgical improvements.

Methods

A total of 58 cases including 32 cases of BCC, 13 cases of Bowen's disease, 8 cases of Paget's disease and 5 cases of SCC were included in this study. All cases were treated with topical ALA-PDT after surgery. Each tumor region was irradiated with 120 J/cm² using a 635-nm laser for 15 min. A total of 3 times of assisted ALA-PDT was applied after surgery.

Results

There was no recurrence in 6 months after treatment. Only 5 cases of Paget's disease and 2 cases of SCC experienced disease recurrence in 1 year. All patients were able to complete the treatment protocol, with well cosmetic results and no moderate adverse reactions.

Conclusions

As an assistive therapy after tumor resection, ALA-PDT can reduce the excision range of the tumor lesions. However, its role in the reduction of recurrence rate remains to be further investigated.