Particulate matter exposure induces the autophagy of macrophages via oxidative stress-mediated PI3K/AKT/mTOR pathway
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- 作者：Ruijun Sua ; 1 ; Xiaoting Jina ; b ; 1 ; Weifang Zhangc ; Zhuoyu Lia ; lzy@sxu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xiaona Liua ; Jie Rend
- 关键词：PM2.5 ; Pulmonary macrophage ; Autophagy ; Oxidative stress ; PI3K/AKT/mTOR pathway
- 刊名：Chemosphere
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：167
- 期：Complete
- 页码：444-453
- 全文大小：1975 K
文摘
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PM2.5 exposure decreased numbers of immune cells in SD rats BALF.
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PM2.5 could induce the autophagy of pulmonary macrophages in SD rats and Raw264.7 cells.
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PM2.5 exposure led to the activation of oxidative stress in Raw264.7 cells.
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PM2.5 induced cell autophagy via the oxidative stress-mediated PI3K/AKT/mTOR pathway.