Immune-mediated disease and secondary failure to oral therapy in type 2 diabetes mellitus

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• 作者：Avilé ; s-Santa ; Larissa ; Maclaren ; Noel ; Raskin ; Philip
• 关键词：Autoimmune diabetes ; Type 2 diabetes ; Ethnicity
• 刊名：Journal of Diabetes and its Complications
• 出版年：2004
• 出版时间：January 2, 2004
• 年：2004
• 卷：18
• 期：1
• 页码：10-17
• 全文大小：169 K

文摘

Purpose: To determine the proportion of adults with type 2 diabetes, who developed secondary failure to oral medications that had immune-mediated diabetes (IMD). Subjects and methods: One hundred and eight subjects who failed to oral therapy were screened for autoantibodies (ICA, IAA, IA-2A, and GADA₆₅) and HLA DR/DQ markers of IMD. Results: Mean age was 49 years and mean body mass index (BMI) was 31.5 kg/m²; 21.3 % were non-Hispanic White (NHW), 32.3 % Latin American (LA), and 43.2 % African American (AA). Fourteen percent had one or more autoantibodies [Ab(+)]: five NHW, three LA, and seven AA. Ab(+) patients were younger (P