A fast-responsive turn on fluorescent probe for detecting endogenous hydroxyl radicals based on a hybrid carbazole-cyanine platform
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- 作者：Jian-Yong WangAuthor Vitae ; Zhan-Rong LiuAuthor Vitae ; Mingguang RenAuthor Vitae ; Xiuqi KongAuthor Vitae ; Keyin LiuAuthor Vitae ; Beibei DengAuthor Vitae ; Weiying Lin ; weiyinglin2013@163.com" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Fluorescent probe ; Hydroxyl radicals ; Living cells
- 刊名：Sensors & Actuators: B. Chemical
- 出版年：2016
- 出版时间：29 November 2016
- 年：2016
- 卷：236
- 期：Complete
- 页码：60-66
- 全文大小：1505 K
文摘
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A novel turn on fluorescent probe based on a hybrid carbazole-cyanine platform was designed and synthesized for detecting hydroxyl radicals in living cells.
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The CCy-OH probe had exhibited ideal properties including fast response (0.5 min), good selectivity, and low cytotoxicity.
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Almost 60-fold fluorescence enhancement was obtained when the probe was treated with
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OH in solution with excitation at 510 nm and emission at 604 nm.
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Fluorescence imaging shows that the novel CCy-OH probe is membrane-permeable and suitable for detecting endogenous hydroxyl radicals in living cells.