Interferon response of the cystic fibrosis bronchial epithelium to major and minor group rhinovirus infection

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• 作者：Aline Schö ; gler^a ; ^b ; ^c ; Andrea B. Stokes^a ; ^b ; Carmen Casaulta^a ; Nicolas Regamey^d ; Michael R. Edwards^e ; Sebastian L. Johnston^e ; Andreas Jung^f ; Alexander Moeller^f ; Thomas Geiser^b ; ^g ; Marco P. Alves^a ; ^b ; ^{marco.alves@dkf.unibe.ch" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cystic fibrosis ; Rhinovirus ; Interferon ; Bronchial epithelial cells
• 刊名：Journal of Cystic Fibrosis
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：15
• 期：3
• 页码：332-339
• 全文大小：334 K

文摘

Rhinoviruses (RVs) are associated with exacerbations of cystic fibrosis (CF), asthma and COPD. There is growing evidence suggesting the involvement of the interferon (IFN) pathway in RV-associated morbidity in asthma and COPD. The mechanisms of RV-triggered exacerbations in CF are poorly understood. In a pilot study, we assessed the antiviral response of CF and healthy bronchial epithelial cells (BECs) to RV infection, we measured the levels of IFNs, pattern recognition receptors (PRRs) and IFN-stimulated genes (ISGs) upon infection with major and minor group RVs and poly(IC) stimulation. Major group RV infection of CF BECs resulted in a trend towards a diminished IFN response at the level of IFNs, PRRs and ISGs in comparison to healthy BECs. Contrary to major group RV, the IFN pathway induction upon minor group RV infection was significantly increased at the level of IFNs and PRRs in CF BECs compared to healthy BECs.