The p53 gene mutation is of prognostic value in esophageal squamous cell carcinoma patients in unified stages of curability

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• 作者：Kobayashi ; Susumu ; Koide ; Yoshio ; Endo ; Masato ; Isono ; Kaichi ; Ochiai ; Takenori
• 刊名：The American Journal of Surgery
• 出版年：1999
• 出版时间：June, 1999
• 年：1999
• 卷：177
• 期：6
• 页码：497-502
• 全文大小：191 K

文摘

Background: The p53 gene alteration is identified in approximately half of all human tumors, and is now thought to be a key gene for regulating the cell cycle through the induction of p21^WAF1/CIP1 and inducing apoptosis through some genes such as BAX. In this study, we investigated the prognostic value of p53 mutation for postoperative esophageal squamous cell carcinoma patients.