Antitumor effect induced by the expression of granulocyte macrophage-colony stimulating factor gene in murine colon carcinoma cells
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- 作者：Yoshio Gunji ; Masatoshi Tagawa ; Hisahiro Matsubara ; Keizo Takenaga ; Hideaki Shimada ; Fukuo Kondo ; Takao Suzuki ; Kazuaki Nakajima ; Makoto Sugaya ; Takehide Asano ; Takenori Ochiai ; Kaichi Isono ; Keisuke Horitsu ; Hajime Kageyama ; Yohko Nakamura ; Shigeru Sakiyama
- 刊名：Cancer Letters
- 出版年：1996
- 出版时间：29 March 1996
- 年：1996
- 卷：101
- 期：2
- 页码：257-261
- 全文大小：803 K
文摘
Murine colon carcinoma cells which secrete several kinds of cytokine after retroviral transduction with corresponding genes, were examined for their antitumor effects in syngeneic mice. The mice inoculated with granulocyte macrophage colony stimulating factor (GM-CSF) producer cells showed not only prolonged survival but also reduced tumorigenicity. The antitumor effect caused by the expression of interleukin-4 was less than that of GM-CSF, and interleukin-6 producer cells did not show any effects on the survival of the host animals. Histological examination of the GM-CSF-producing tumor revealed predominant infiltration of neutrophils and necrotic change of the tumor. The present study indicates the feasibility of cancer gene therapy with the expression of GM-CSF gene in tumor cells.