Combination and comparison of two models in prognosis of pulmonary embolism: Results from TUrkey Pulmonary Embolism Group (TUPEG) study

详细信息    查看全文

• 作者：Savas Ozsu^a ; ^{savasozsu@gmail.com" class="auth_mail} ; Tevfik Ozlu^a ; ^{ozlutevfik@yahoo.com" class="auth_mail} ; Ay艧eg&uuml ; l 艦ent&uuml ; rk^b ; ^{asenturk1967@yahoo.com" class="auth_mail} ; Elif Y谋lmazel Uç ; ar^c ; ^{eucar1979@yahoo.com" class="auth_mail} ; Gamze K谋rk谋l^d ; ^{gamkirkil@yahoo.com" class="auth_mail} ; Esra Ekbiç ; Kad谋o臒lu^e ; ^{esraekbic@hotmail.com" class="auth_mail} ; B&uuml ; lent Alt谋nsoy^f ; ^{balt1907@yahoo.com" class="auth_mail} ; Beng&uuml ; 艦aylan^g ; ^{metebengu@yahoo.com" class="auth_mail} ; Hatice 艦en Selimo臒lu^h ; ^{dr.haticesen@hotmail.com" class="auth_mail} ; G&uuml ; l Dabakⁱ ; ^{dgrdabak@hotmail.com" class="auth_mail} ; Nuri Tutar^j ; ^{drnuritutar@gmail.com" class="auth_mail} ; Ahmet Uysal^k ; ^{ahmet-bh@hotmail.com" class="auth_mail} ; On behalf of the TUPEG Study Investigators Hayriye Bektas ; Sevinc Sarinc ; Ebru Ç ; ak谋r ; Serap Duru ; Ersin G&uuml ; nay ; Seyma Baslilar ; G&uuml ; lbahar Dar谋lmaz ; Nilg&uuml ; n Demirci ; Fusun Alata艧 ; Ezgi Demirdö ; 臒en ; Servet Kayhan ; Serdar Berk ; Ayg&uuml ; l G&uuml ; zel ; Fatih Yakar ; Fatmanur Karakö ; se ; Selami Ekin ; Nalan Demir ; &Uuml ; mran Toru ; Dursun Tatar ; Tulin Kuyucu ; Ö ; zlem Kar Kurt ; Nagehan Durmu艧 ; P谋nar Y谋ld谋z ; Aydanur Ekici ; Murat Acat ; Serhat Ç ; elikel ; Mehmet Yav艧an ; Sibel Ar谋nç ; Ay艧e Bahad谋r ; Funda Ç ; o艧kun ; Nesrin Mo臒ulkoç ; Sulhattin Arslan ; 陌smail Sava艧
• 刊名：Thrombosis Research
• 出版年：June 2014
• 年：2014
• 卷：133
• 期：6
• 页码：1006-1010
• 全文大小：277 K

文摘

Clinical parameters, biomarkers and imaging-based risk stratification are widely accepted in pulmonary embolism(PE). The present study has investigated the prognostic role of simplified Pulmonary Embolism Severity Index (sPESI) score and the European Society of Cardiology (ESC) model.

Methods

This prospective cohort study included a total of 1078 patients from a multi-center registry, with objectively confirmed acute symptomatic PE. The primary endpoint was all-cause mortality during the first 30 days, and the secondary endpoint included all-cause mortality, nonfatal symptomatic recurrent PE, or nonfatal major bleeding.

Results

Of the 1078 study patients, 95 (8.8%) died within 30 days of diagnosis. There was no significant difference between non-low-risk patients ESC [12.2% (103 of 754;)] and high-risk patients as per the sPESI [11.6% (103 of 796)] for 30-day mortality. The nonfatal secondary endpoint occurred in 2.8% of patients in the the sPESI low-risk and 1.9% in the ESC low-risk group. Thirty-day mortality occurred in 2.2% of patients the sPESI low-risk and in 2.2% the ESC low-risk group (P = NS). In the present study, in the combination of the sPESI low-risk and ESC model low-risk mortality rate was 0%.

Conclusions

The sPESI and the ESC model showed a similar performance regarding 30-day mortality and secondary outcomes in the present study. However, the combination of these two models appears to be particularly valuable in PE.