LC-ESI-MS/MS evaluation of forced degradation behaviour of silodosin: In vitro anti cancer activity evaluation of silodosin and major degradation products

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• 作者：Chiguru Vishnuvardhan^a ; Baikadi Saibaba^a ; Lingesh Allakonda^c ; Debasish Swain^a ; S. Gananadhamu^a ; R. Srinivas^a ; ^b ; ^{srini@iict.res.in} ; N. Satheeshkumar^a ; ^{satish.niperhyd@gov.in}
• 关键词：Forced degradation ; LC&ndash ; MS/MS ; Isolation of DPs ; Anti cancer activity ; MTT assay
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：134
• 期：Complete
• 页码：1-10
• 全文大小：2839 K
• 卷排序：134

文摘

Forced degradation studies of silodosin under hydrolytic (acidic, alkaline and neutral), oxidation, photolysis and thermal stress conditions. Isolation of major degradation products (DP 1 and DP 2). Identification of 5 hitherto unknown DPs by LC–ESI–MS/MS experiments. In vitro anticancer activity studies on silodosin, DP 1 and DP 2 using PC 3 cells by MTT assay.