Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode

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• 作者：Jelena Lović^a ; Nemanja Tri&scaron ; ović^b ; Jelena Antanasijević^b ; Neboj&scaron ; a D. Nikolić^a ; Sanja Stevanović^a ; Du&scaron ; an Mijin^b ; Dragan Vuković^c ; Aleksandar Mladenović^d ; Slobodan Petrović^b ; Milka Avramov Ivić^a ; ^{milka@tmf.bg.ac.rs}
• 关键词：Sildenafil citrate ; Au/Cys electrode ; Human serum analysis ; Surface microscopic analysis
• 刊名：Journal of Electroanalytical Chemistry
• 出版年：2016
• 出版时间：1 December 2016
• 年：2016
• 卷：782
• 期：Complete
• 页码：103-107
• 全文大小：1095 K
• 卷排序：782

文摘

Clinical needs caused the new method development for SC determination. SWV method for SC standard, tablet and in human serum in 0.05 M NaHCO3 is applied. In 0.1 M H2SO4 for SC standard and tablet catalytic effect of Au/Cys is observed. SWV is more sensitive than HPLC and can be used for very low concentrations of SC. Microscopic characterization of the morphology of the used electrode surfaces.