Chronic renal transplantation: a model for the hyperhomocysteinemia of renal insufficiency

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• 作者：Bostom ; Andrew G. ; Kronenberg ; Florian ; Gohh ; Reginald Y. ; Schwenger ; Vedat ; Kuen ; Erich ; Kö ; nig ; Paul ; et. al.
• 关键词：Renal function ; Homocysteine ; Immunosuppressive drugs ; Clinical trials
• 刊名：Atherosclerosis
• 出版年：2001
• 出版时间：May, 2001
• 年：2001
• 卷：156
• 期：1
• 页码：227-230
• 全文大小：68.0 K

文摘

Renal transplant recipients (RTR) are considered representative of patients with chronic renal insufficiency (CRI) in general with respect to both reduced, progressively declining renal function, and increased risk for cardiovascular disease (CVD). In accord with this argument, we hypothesized that total (t) plasma concentrations of the putatively atherothrombotic amino acid homocysteine (Hcy) would be equivalent in RTR and CRI patients with comparable renal function. We determined plasma tHcy, folate, pyridoxal 5′-phosphate, and B12 concentrations, in addition to serum creatinine and albumin concentrations, in 86 chronic, stable RTR, and 238 patients with CRI. Within comparable ranges of serum creatinine (i.e. RTR=0.6–4.2 mg/dl; CRI=0.7–4.1 mg/dl), tHcy concentrations did not differ between the two groups (RTR=15.0 μmol/l; CRI=14.9 μmol/l, P