Vitamin K3 (menadione) redox cycling inhibits cytochrome P450-mediated metabolism and inhibits parathion intoxication
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- 作者：Yi-Hua Jana ; Jason R. Richardsona ; jricha3@eohsi.rutgers.edu" class="auth_mail" title="E-mail the corresponding author ; Angela A. Bakera ; Vladimir Mishinb ; Diane E. Heckc ; Debra L. Laskinb ; Jeffrey D. Laskina ; jlaskin@eohsi.rutgers.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Parathion ; Cytochrome P450 system ; Cytochrome P450 reductase ; Menadione ; Redox cycling
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2015
- 出版时间：1 October 2015
- 年：2015
- 卷：288
- 期：1
- 页码：114-120
- 全文大小：745 K
文摘
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Menadione redox cycles with cytochrome P450 reductase and generates reactive oxygen species.
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Redox cycling inhibits cytochrome P450-mediated parathion metabolism.
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Short term administration of menadione inhibits parathion toxicity by inhibiting paraoxon formation.