刊名:Biochimica et Biophysica Acta (BBA) - General Subjects
出版年:2017
出版时间:January 2017
年:2017
卷:1861
期:1
页码:3474-3489
全文大小:2148 K
卷排序:1861
文摘
GabR binds two DNA direct repeats as a dimer and bends the cognate site by ~ 80°. Proper phasing of direct repeats is crucial for GabR binding. PLP is not required for the GabR-DNA interaction. GABA reduces GabR-DNA affinity and alters slightly the shape of the complexes. Basic residues of the AT domain affect GabR-DNA binding affinity.