Brain iron deficiency in idiopathic restless legs syndrome measured by quantitative magnetic susceptibility at 7 tesla
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- 作者：Xu Lia ; b ; xuli@mri.jhu.edu" class="auth_mail" title="E-mail the corresponding author ; Richard P. Allenc ; Christopher J. Earleyc ; Hongjun Liua ; b ; d ; Tiana E. Cruzc ; Richard A.E. Eddena ; b ; Peter B. Barkera ; b ; Peter C.M. van Zijla ; b
- 关键词：Restless legs syndrome ; Brain iron deficiency ; Periodic limb movement during sleep ; Quantitative susceptibility mapping
- 刊名：Sleep Medicine
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：22
- 期：Complete
- 页码：75-82
- 全文大小：1061 K
文摘
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7 T quantitative susceptibility mapping reveals brain iron deficiency in idiopathic restless legs syndrome (RLS) patients off treatment.
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RLS patients showed decreased iron in thalamus and dentate nucleus.
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Decreased iron in the substantia nigra (SN) correlated with increased periodic limb movement during sleep (PLMS) for RLS.
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Iron deficiency in SN was observed in RLS with severe PLMS.