Effect of implanted Cu/low-density polyethylene nanocomposite on the morphology of endometrium in the mouse

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• 作者：Xianping Xia ; Changsheng Xie ; Changhong Zhu ; Shuizhou Cai ; Xiangliang Yang
• 关键词：Cu/LDPE nanocomposite ; bulk copper ; IUD ; endometrium ; contraception ; mice
• 刊名：Fertility and Sterility
• 出版年：2007
• 出版时间：August 2007
• 年：2007
• 卷：88
• 期：2
• 页码：472-478
• 全文大小：1044 K

文摘

Objective

To investigate the damage of endometrium caused by the implanted Cu/low-density polyethylene (LDPE) nanocomposite and the contraceptive effect of this novel copper-containing intrauterine device material.

Design

Experimental animal study.

Setting

TongJi Medical College of Huazhong University of Science and Technology.

Patient(s)

Sixty healthy female mice.

Intervention(s)

Twenty mice received no implants, 20 mice received the Cu/LDPE nanocomposite, and 20 mice received bulk copper.

Main Outcome Measure(s)

Morphologic features of the endometrium, contraceptive effect, and surface condition of the implanted implants.

Result(s)

The contraceptive effect of both the Cu/LDPE nanocomposite and bulk copper is 100 % , the damage of the endometrium caused by the Cu/LDPE nanocomposite is much less than that caused by bulk copper, and the surface of the implanted Cu/LDPE nanocomposite is much smoother and much softer than that of the implanted bulk copper.

Conclusion(s)

The contraceptive effect of the Cu/LDPE nanocomposite is comparable with that of bulk copper, and the damage of the endometrium caused by the Cu/LDPE nanocomposite is much less than that caused by bulk copper. The endometrium injury is related to the surface condition of the implanted intrauterine device material.