Passive immunisation of post-weaned piglets using hyperimmune serum against experimental Haemophilus parasuis infection

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• 作者：K.  ; Nedbalcova  ; ;   ; ^{nedbalcova@vri.cz} ; Z.  ; Kucerova ; J.  ; Krejci ; R.  ; Tesarik ; E.  ; Gopfert ; V.  ; Kummer ; L.  ; Leva ; H.  ; Kudlackova ; R.  ; Ondriasova ; M.  ; Faldyna
• 关键词：Haemophilus parasuis ; Passive immunisation ; Hyperimmune serum ; Challenge ; Piglets
• 刊名：Research in Veterinary Science
• 出版年：2011
• 出版时间：October 2011
• 年：2011
• 卷：91
• 期：2
• 页码：225-229
• 全文大小：317 K

文摘

The protective role of hyperimmune serum in the prevention of Haemophilus parasuis infections in post-weaned piglets was assessed by experimental challenge. The hyperimmune serum was obtained from a pig vaccinated with a commercial vaccine against Gl?sser¡¯s disease. Thirty-eight weaned piglets were divided into four groups: three groups were immunised intramuscularly with 10 ml of hyperimmune serum and one group consisted of unimmunised control animals. All piglets were subsequently infected intraperitoneally with H. parasuis serotype 5 at different times after immunisation. The use of hyperimmune serum provided the piglets with partial protection against experimental infection. The levels of protection indirectly depend on time between serum inoculation and challenge infection. The best protection of piglets against experimental infection was obtained in the group immunised 1 week before inoculation; the same group in which the highest levels of antibodies were detected at the time of challenge.