Risk factors for cardiopulmonary dysfunction in early-onset severe pre-eclampsia

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• 作者：Fei Guan¹ ; Jing Ye¹ ; Jianhua Lin ; ^{linjhuarj@126.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cardiac function ; Early-onset severe pre-eclampsia ; Expectant management ; Pulmonary function
• 刊名：International Journal of Gynecology and Obstetrics
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：135
• 期：2
• 页码：192-195
• 全文大小：264 K

文摘

To explore associations between patient characteristics and cardiopulmonary function among patients with early-onset severe pre-eclampsia being treated with expectant management.

Method

The present retrospective study included patients who received expectant management for early-onset pre-eclampsia between January 1 and December 31, 2014 at Shanghai Jiao Tong University School of Medicine, China. Patients were divided into two groups based on cardiopulmonary function, a decompensatory group and a normal group. The clinical characteristics of patients in the two groups were compared by binary logistic regression analysis and using the Student t test.

Results

Data from 93 patients were included in the analysis. Serum creatinine levels (P = 0.017), ascites (P = 0.001), and increased proteinuria (P = 0.015) were associated with decompensation of cardiopulmonary function during early-onset severe pre-eclampsia. Hypoproteinemia was associated with significantly increased odds of ascites occurring (odds ratio 3.16; 95% confidence interval 1.34–7.44) and the mean serum albumin level was higher in patients without ascites (P < 0.001).

Conclusions

Renal insufficiency and ascites were associated with cardiopulmonary dysfunction. Ascites should receive greater medical attention during the expectant management of early-onset severe pre-eclampsia.