BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo
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- 作者：Mihaela Crisan1 ; 2 ; Parham Solaimani Kartalaei1 ; 3 ; Alex Neagu1 ; Sofia Karkanpouna1 ; Tomoko Yamada-Inagawa1 ; Caterina Purini1 ; Chris S. Vink1 ; 3 ; Reinier van der Linden1 ; Wilfred van Ijcken4 ; Susana M. Chuva de Sousa Lopes5 ; Rui Monteiro6 ; Christine Mummery5 ; Elaine Dzierzak1 ; 3 ; elaine.dzierzak@ed.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：hematopoietic stem/progenitor cells ; HPSCs ; AGM ; BMP ; Hh ; VEGF ; development ; hematopoiesis
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：8 March 2016
- 年：2016
- 卷：6
- 期：3
- 页码：383-395
- 全文大小：2533 K
文摘
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AGM explants contain two HSC types, BMP-activated and non-BMP-activated
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Non-BMP-activated HSCs are dependent on Hedgehog/VEGF
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Changes in the microenvironment ex vivo contribute to novel HSC composition