Decreased expression of IL-27 in moderate-to-severe psoriasis and its anti-inflammation role in imiquimod-induced psoriasis-like mouse model

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• 作者：Wenjuan Chen^a ; ¹ ; Yu Gong^a ; ¹ ; Xilin Zhang^b ; ¹ ; Yunlei Tong^a ; Xiuxiu Wang^c ; Chengwen Fei^a ; Hui Xu^a ; Qian Yu^a ; Yao Wang^a ; Yuling Shi^a ; ^{shiyuling1973@tongji.edu.cn}
• 关键词：Psoriasis ; IL-27 ; Th17 ; Imiquimod
• 刊名：Journal of Dermatological Science
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：85
• 期：2
• 页码：115-123
• 全文大小：2493 K
• 卷排序：85

文摘

The expression levels of IL-27 and IL-27Rα were significantly reduced in psoriasis patients in both protein and RNA levels. Topical administration with IL-27 can alleviate the clinical manifestation of imiquimod-induced mouse model. IL-27 could suppress the function of Th17 cells in imiquimod-induced mouse models.