Mosquito Defense Strategies against Viral Infection

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• 作者：Gong Cheng¹ ; ^{gongcheng@mail.tsinghua.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Yang Liu¹ ; ² ; Penghua Wang³ ; Xiaoping Xiao¹
• 关键词：mosquito ; arbovirus ; antiviral immunity
• 刊名：Trends in Parasitology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：32
• 期：3
• 页码：177-186
• 全文大小：1844 K

文摘

Mosquito-borne viral diseases are a major concern of global health and result in significant economic losses in many countries. As natural vectors, mosquitoes are very permissive to and allow systemic and persistent arbovirus infection. Intriguingly, persistent viral propagation in mosquito tissues neither results in dramatic pathological sequelae nor impairs the vectorial behavior or lifespan, indicating that mosquitoes have evolved mechanisms to tolerate persistent infection and developed efficient antiviral strategies to restrict viral replication to nonpathogenic levels. Here we provide an overview of recent progress in understanding mosquito antiviral immunity and advances in the strategies by which mosquitoes control viral infection in specific tissues.