Modulatory role of the anti-apoptotic protein kinase CK2 in the sub-cellular localization of Fas associated death domain protein (FADD)
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- 作者：Valé ; rie Vilmonta ; b ; 1 ; Odile Filholc ; Anne-Marie Hessed ; Yohann Couté ; d ; Christophe Huea ; e ; Lé ; a Ré ; my-Tourneurb ; Sylvie Mistoub ; Claude Cochetc ; 2 ; claude.cochet@cea.fr" class="auth_mail" title="E-mail the corresponding author ; Gilles Chiocchiaa ; e ; 2 ; gilles.chiocchia@inserm.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：FADD ; Fas associated death domain ; CK2 ; Casein kinase 2 ; TBB ; 4 ; 5 ; 6 ; 7-Tetrabromo-2-azabenzimidazole ; 4 ; 5 ; 6 ; 7-Tetrabromobenzotriazole
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：1853
- 期：11
- 页码：2885-2896
- 全文大小：1999 K
文摘
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A new regulatory mechanism for nuclear FADD retention is proposed.
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Anti-apoptotic kinase, CK2, phosphorylates FADD at serine 200.
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Phosphorylation of FADD by CK2 induces nuclear retention of FADD.