The importin protein karyopherin-β1 regulates the mice fibroblast-like synoviocytes inflammation via facilitating nucleus transportation of STAT3 transcription factor
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- 作者：Chi Suna ; 1 ; franksunchi@163.com" class="auth_mail" title="E-mail the corresponding author ; Zhaohui Yua ; 1 ; yuzhaohui134@163.com" class="auth_mail" title="E-mail the corresponding author ; Youhua Wangb ; wyh20151224@yeah.net" class="auth_mail" title="E-mail the corresponding author ; Tao Taoa ; tao_tao0324@yeah.net" class="auth_mail" title="E-mail the corresponding author
- 关键词：Rheumatoid arthritis ; KPNB1 ; STAT3 ; IL-1β ; Fibroblast-like synoviocytes
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：18 March 2016
- 年：2016
- 卷：471
- 期：4
- 页码：553-559
- 全文大小：1477 K
文摘
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STAT3 can induce MMP-3 and IL-6 secretion in fibroblast-like synoviocytes.
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KPNB1 participates in the nucleus transportation of STAT3.
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Silencing of KPNB1 could inhibit MMP-3 and IL-6 secretion in fibroblast-like synoviocytes through STAT3 pathway.