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A universal locked nucleic acid-integrated X-shaped DNA probe design for amplified fluorescence detection of single-nucleotide variant
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文摘
An enzyme-free and selective fluorescence biosensor for β-thalassemia SNV detection is proposed based on X-shaped probe. Locked nucleic acid integrated in X-shaped DNA probe improves the stability and specificity of the sensor. Signal amplification of the fluorescence biosensor lies in the toehold-mediated strand-displacement reaction assisted recycling.

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