Thalidomide represses inflammatory response and reduces radiculopathic pain by inhibiting IRAK-1 and NF-κB/p38/JNK signaling
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- 作者：Tieying Songa ; 1 ; tysong1234@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiaojing Maa ; 1 ; Kunfeng Gua ; Yunliang Yangc ; Lijun Yanga ; Pengxu Maa ; Wenli Wangb ; Jianhui Zhaoa ; Ruyv Yana ; Jiao Guana ; Chunping Wanga ; Yan Qia ; Jian Yaa
- 关键词：IVD ; intervertebral disc disease ; MMPs ; metalloproteinases ; IRAK-1 ; interleukin-1 receptor-associated kinase 1 ; iNOS ; inducible nitric oxide synthase
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：290
- 期：Complete
- 页码：1-8
- 全文大小：958 K
文摘
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Thalidomide inhibited the expression of pro-inflammatory mediators in vitro.
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Thalidomide inhibited the expression of matrix metalloproteinases in vitro.
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Thalidomide inhibited the expression of radiculopathic pain in vivo.
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Thalidomide could treat pain and inflammation in degenerative disc disease.