Cytokines and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants

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• 作者：Waldemar A. Carlo ; MD^a ; ^{wcarlo@peds.uab.edu} ; Scott A. McDonald ; BS^b ; Jon E. Tyson ; MD ; MPH^c ; Barbara J. Stoll ; MD^d ; Richard A. Ehrenkranz ; MD^e ; Seetha Shankaran ; MD^f ; Ronald N. Goldberg ; MD^g ; Abhik Das ; PhD^h ; Diana Schendel ; PhDⁱ ; Poul Thorsen ; MD^j ; Kristin Skogstrand ; PhD^l ; David M. Hougaard ; MD^l ; William Oh ; MD^m ; Abbot R. Laptook ; MDⁿ ; Shahnaz Duara ; MD^o ; Avroy A. Fanaroff ; MD^p ; Edward F. Donovan ; MD^q ; Sheldon B. Korones ; MD^r ; David K. Stevenson ; MD^s ; Lu-Ann Papile ; MD^t ; Neil N. Finer ; MD^u ; T. Michael O&rsquo ; Shea ; MD ; MPH^v ; Brenda B. Poindexter ; MD ; MS^w ; Linda L. Wright ; MD^x ; Namasivayam Ambalavanan ; MD^a ; Rosemary D. Higgins ; MD^x ; Eunice Kennedy Shriver National Institute of Child Health ; Human Development Neonatal Research Network &lowast
• 关键词：CP ; Cerebral palsy ; ELBW ; Extremely low birth weight ; IL ; Interleukin ; MDI ; Mental Development Index ; PDI ; Psychomotor Development Index ; RANTES ; Regulated upon activation ; normal T-cell expressed ; and secreted ; TNF ; Tumor necrosis factor
• 刊名：The Journal of Pediatrics
• 出版年：2011
• 出版时间：December, 2011
• 年：2011
• 卷：159
• 期：6
• 页码：919-925.e3
• 全文大小：309 K

文摘

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Objective

To determine if selected pro-inflammatory and anti-inflammatory cytokines and/or mediators of inflammation reported to be related to the development of cerebral palsy (CP) predict neurodevelopmental outcome in extremely low birth weight infants.

Study design

Infants with birth weights ¡Ü1000 g (n = 1067) had blood samples collected at birth and on days 3?¡À?1, 7 ¡À 1, 14 ¡À 3, and 21 ¡À 3 to examine the association between cytokines and neurodevelopmental outcomes. The analyses were focused on 5 cytokines (interleukin [IL] 1¦Â; IL-8; tumor necrosis factor-¦Á; regulated upon activation, normal T-cell expressed, and secreted (RANTES); and IL-2) reported to be most predictive of CP in term and late preterm infants.

Results

IL-8 was higher on days 0-4 and subsequently in infants who developed CP compared with infants who did not develop CP in both unadjusted and adjusted analyses. Other cytokines (IL-12, IL-17, tumor necrosis factor-¦Â, soluble IL r¦Á, macrophage inflammatory protein 1¦Â) were found to be altered on days 0-4 in infants who developed CP.

Conclusions

CP in former preterm infants may, in part, have a late perinatal and/or early neonatal inflammatory origin.