Highly selective non-opioid kappa opioid receptor (KOR) agonist salvinorin A protects against forebrain ischemia-induced brain injury in rats
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- 作者：Jihua Xin ; Yan Zhang ; Zhenzhou He ; Zhenhong Wang<sup> ; sup><sup>Zhenhong_Wang1@yeah.net" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Aquaporin-4 (AQP4) ; Cerebral edema ; Ischemia/reperfusion ; Kappa opioid agonist ; Salvinorin A ; Motor function ; Cognition
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：1637
- 期：Complete
- 页码：168-176
- 全文大小：6200 K
文摘
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Salvinorin A attenuated forebrain ischemia-induced brain injury and edema.
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Motor function on 1, 2 and 5 days and cognitive 5–9 days post-ischemia were improved by Salvinorin A.
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Salvinorin A lessened forebrain ischemia-induced upregulation of AQP4 expression.
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KOR may involve in the mechanism for Salvinorin A exerting neuroprotective effects.
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Salvinorin A is a promising therapeutic agent for cerebral ischemia.