Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin
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- 作者：Chun-Jun Guo ; Benjamin P. Knox ; Yi-Ming Chiang ; Hsien-Chun Lo ; James F. Sanchez ; Kuan-Han Lee ; Berl R. Oakley ; Kenneth S. Bruno ; Clay C. C. Wang
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：November 16, 2012
- 年：2012
- 卷：14
- 期：22
- 页码：5684-5687
- 全文大小：298K
- 年卷期：v.14,no.22(November 16, 2012)
- ISSN：1523-7052
文摘
Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evolutionarily.