Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells
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- 作者：Yoshitomo Suhara ; Yoshihisa Hirota ; Norika Hanada ; Shun Nishina ; Sachiko Eguchi ; Rie Sakane ; Kimie Nakagawa ; Akimori Wada ; Kazuhiko Takahashi ; Hiroaki Tokiwa ; Toshio Okano
- 刊名：Journal of Medicinal Chemistry
- 出版年：2015
- 出版时间：September 10, 2015
- 年：2015
- 卷：58
- 期：17
- 页码：7088-7092
- 全文大小：300K
- ISSN：1520-4804
文摘
We synthesized new vitamin K2 analogues with 蠅-terminal modifications of the side chain and evaluated their selective differentiation of neuronal progenitor cells into neurons in vitro. The result of the assay showed that the menaquinone-3 analogue modified with the m-methylphenyl group had the most potent activity, which was twice as great as the control. This finding indicated that it is possible to obtain much more potent compounds with modification of the structure of vitamin K2.