Selenoacyclovir and Selenoganciclovir: Discovery of a New Template for Antiviral Agents
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- 作者：Pramod K. Sahu ; Tamima Umme ; Jinha Yu ; Akshata Nayak ; Gyudong Kim ; Minsoo Noh ; Jae-Young Lee ; Dae-Duk Kim ; Lak Shin Jeong
- 刊名：Journal of Medicinal Chemistry
- 出版年：2015
- 出版时间：November 12, 2015
- 年：2015
- 卷：58
- 期：21
- 页码：8734-8738
- 全文大小：308K
- ISSN：1520-4804
文摘
On the basis of the potent antiviral activity of acyclovir and ganciclovir, selenoacyclovir (2a) and selenoganciclovir (2b) were designed based on bioisoteric rationale and synthesized via the diselenide 7 as the key intermediate. Compound 2a exhibited potent anti-HSV-1 and -2 activities while 2b exerted moderate anti-HCMV activity, indicating that these nucleosides can serve as a novel template for the development of new antiviral agents.