An X-ray Spectromicroscopy Study of Protein Adsorption to Polystyrene−Poly(ethylene oxide) Blends

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• 作者：Bonnie O. Leung ; Adam P. Hitchcock ; John L. Brash ; Andreas Scholl ; Andrew Doran
• 刊名：Langmuir
• 出版年：2010
• 出版时间：September 21, 2010
• 年：2010
• 卷：26
• 期：18
• 页码：14759-14765
• 全文大小：1044K
• 年卷期：v.26,no.18(September 21, 2010)
• ISSN：1520-5827

文摘

Synchrotron-based X-ray photoemission electron microscopy (X-PEEM) and atomic force microscopy (AFM) were used to characterize the composition and surface morphology of thin films of a polystyrene−poly(ethylene oxide) blend (PS−PEO), spun cast from dichloromethane at various mass ratios and polymer concentrations. X-PEEM reveals incomplete segregation with 30% of PS in the PEO region and vice versa. Protein (human serum albumin) adsorption studies show that this partial phase separation leads to greater protein repellency in the PS region, whereas more protein is detected in the PEO region compared to control samples.