Tricyclic Alkaloid Core Structures Assembled by a Cyclotrimerization−Coupled Intramolecular Nucleophilic Substitution Reaction

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• 作者：Andrew L. McIver ; Alexander Deiters
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：March 19, 2010
• 年：2010
• 卷：12
• 期：6
• 页码：1288-1291
• 全文大小：234K
• 年卷期：v.12,no.6(March 19, 2010)
• ISSN：1523-7052

文摘

A facile approach to tricyclic alkaloid core structures was developed by sequencing a pyridine-forming [2 + 2 + 2] cyclotrimerization reaction with an intramolecular nucleophilic substitution. This methodology enabled the facile assembly of the spiroindolinone framework of citrinadins A and B, and cyclopiamine B.