Poly(Lactic Acid) Hemodialysis Membranes with Poly(Lactic Acid)-block-Poly(2-Hydroxyethyl Methacrylate) Copolymer As Additive: Preparation, Characterization, and Performance
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- 作者：Lijing Zhu ; Fu Liu ; Xuemin Yu ; Lixin Xue
- 刊名：ACS Applied Materials & Interfaces
- 出版年：2015
- 出版时间：August 19, 2015
- 年：2015
- 卷：7
- 期：32
- 页码：17748-17755
- 全文大小：461K
- ISSN：1944-8252
文摘
Poly(lactic acid) (PLA) hemodialysis membranes with enhanced antifouling capability and hemocompatibility were developed using poly(lactic acid)-block-poly(2-hydroxyethyl methacrylate) (PLA鈥揚HEMA) copolymers as the blending additive. PLA鈥揚HEMA block copolymers were synthesized via reversible addition鈥揻ragmentation (RAFT) polymerization from aminolyzed PLA. Gel permeation chromatography (GPC) and 1H-nuclear magnetic resonance (1H NMR) were applied to characterize the synthesized products. By blending PLA with the amphiphilic block copolymer, PLA/PLA鈥揚HEMA membranes were prepared by nonsolvent induced phase separation (NIPS) method. Their chemistry and structure were characterized with X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM) and atomic force microscopy (AFM). The results revealed that PLA/PLA鈥揚HEMA membranes with high PLA鈥揚HEMA contents exhibited enhanced hydrophilicity, water permeability, antifouling and hemocompatibility. Especially, when the PLA鈥揚HEMA concentration was 15 wt %, the water flux of the modified membrane was about 236 L m鈥? h鈥?. Its urea and creatinine clearance was more than 0.70 mL/min, lysozyme clearance was about 0.50 mL/min, BSA clearance was as less as 0.31 mL/min. All the results suggest that PLA鈥揚HEMA copolymers had served as effective agents for optimizing the property of PLA-based membrane for hemodialysis applications.